Long-term survivors of childhood cancer (CCS) have a disproportionate increase in chronic age-related health problems compared to the general population. Survivorship studies have shown that CCS are in an increased pro-inflammatory state with shortened leucocyte telomere length and perturbations of the microbiome. CCS also develop poor muscle strength and increased fatigue, i.e. components of frailty, two to three decades earlier than their peers. Causes of the underlying biologic mechanisms for premature ageing in CCS is an area of active research to identify frontiers where either preventive or therapeutic measures can be instituted.
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