Dr Mohd Fazrul bin Mokhtar is an Emergency Physician and a lecturer at the Universiti Teknologi MARA (UiTM). He obtained his postgraduate training at the National University of Malaysia. Dr Mohd Fazrul has been in the executive committee of Malaysian Sepsis Alliance since its establishment in 2018. He was also the Director of the Malaysian Sepsis Evolution Conference. In UiTM, he oversees the life support trainings, and he has organized many local and international conferences and workshops for doctors and paramedics.
Mild organ dysfunction following a systematic response to infection is usually tolerable if it allows the host to survive and recover. However, the body’s responses also have the potential to cause significant organ failure and death. During sepsis, there are complex phenotypic and functional alterations to the host’s immune systems.
In the first few days of sepsis, the hyperinflammation-induced organ failure is thought to be the most common cause of death. On the other hand, the hypo inflammation or immune paralysis necessitates a prolonged hospitalization, secondary infections, and poor outcomes.
The task to distinguish these phases of sepsis is challenging. During this 15-minute presentation, we will go through the basic yet complex mechanisms of the host's dysregulated immune response to infection as well as understanding the existence of heterogeneity in sepsis.
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